| Download | - View final version: Modern sensor tools and techniques for monitoring, controlling, and improving cell culture processes (PDF, 1.8 MiB)
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| DOI | Resolve DOI: https://doi.org/10.3390/pr10020189 |
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| Author | Search for: Reyes, Sebastian Juan1; Search for: Durocher, Yves1ORCID identifier: https://orcid.org/0000-0002-2268-4111; Search for: Pham, Phuong Lan1ORCID identifier: https://orcid.org/0000-0002-2390-9730; Search for: Henry, Olivier |
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| Affiliation | - National Research Council of Canada. Human Health Therapeutics
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| Funder | Search for: Natural Sciences and Engineering Research Council; Search for: National Research Council Canada |
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| Format | Text, Article |
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| Subject | bioprocess; cell culture; monitoring; PAT; sensors; smart biomanufacturing; soft-sensor; spectroscopy |
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| Abstract | The growing biopharmaceutical industry has reached a level of maturity that allows for the monitoring of numerous key variables for both process characterization and outcome predictions. Sensors were historically used in order to maintain an optimal environment within the reactor to optimize process performance. However, technological innovation has pushed towards on-line in situ continuous monitoring of quality attributes that could previously only be estimated offline. These new sensing technologies when coupled with software models have shown promise for unique fingerprinting, smart process control, outcome improvement, and prediction. All this can be done without requiring invasive sampling or intervention on the system. In this paper, the state-of-the-art sensing technologies and their applications in the context of cell culture monitoring are reviewed with emphasis on the coming push towards industry 4.0 and smart manufacturing within the biopharmaceutical sector. Additionally, perspectives as to how this can be leveraged to improve both understanding and outcomes of cell culture processes are discussed. |
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| Publication date | 2022-02 |
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| Publisher | Elsevier |
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| Licence | |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| Identifier | pr10020189 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 9b8dd80d-153d-4bf6-8cfb-ea733449c4e7 |
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| Record created | 2024-02-27 |
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| Record modified | 2025-11-03 |
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