| Abstract | In the conventional cultivation systems of batch and continuous culture, a number of problems arise which relate to primary and secondary growth and metabolism, maintenance energy, hysteresis effects and the physiological state. In these culture systems the cell population is randomised with the cells in all stages of their development and the results obtained for any experimental parameter examined there reflects the average performance of the cells in the culture and of the microbial activity at that time. But such experimental dimensions do not relate to the critical performer–the cell, and tell us very little of its own individual performance or contribution in the culture. Continuous phased (synchronised) culture enables some measure of the cell performance to be appreciated and results of experiments conducted with Candida utilis are considered in relation to some of the above mentioned problems. |
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