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Structure of the lipopolysaccharide antigenic O-chain produced by Actinobacillus pleuropneumoniae serotype 4 (ATCC 33 378)

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FormatText, Article
Subject1H; acid; Actinobacillus; antigen; antigens, bacterial; bacterial; Canada; carbohydrate conformation; carbohydrate sequence; chromatography, gel; comparative study; epitope; hydrolysis; isolation & purification; Lipopolysaccharide; magnetic resonance spectroscopy; methylation; molecular sequence data; O antigen; O-chain; oxidation-reduction; periodic acid; pleuropneumoniae; repeating unit; serotype; spectroscopy; structure
Abstract
The structure of the antigenic O-polysaccharide part of the S-type lipopolysaccharide produced by Actinobacillus pleuropneumoniae serotype 4 has been determined by periodate oxidation, methylation, partial hydrolysis, and 1H- and 13C-n.m.r. spectroscopy. The O-polysaccharide structure has a branched-tetrasaccharide repeating unit, (----3)-beta-D-Galp-(1----4)-[beta-D-Glcp-(1----3)]-beta-D-GalpNAc- (1----4)-alpha-L-Rhap-(1-)n. The structure resembles that of the lipopolysaccharide O-chain of A. pleuropneumoniae serotype 7, and their common epitopes may account for the apparent serological cross-reactivity observed between the two serotypes when incompletely adsorbed, anticapsular-typing sera are used
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  • Carbohydr.Res. 191, no. 2 (15 August 1989): 295–303.
LanguageEnglish
NRC numberALTMAN1989B
NPARC number9363934
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Record created2009-07-10
Record modified2020-03-17
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