| Download | - View accepted manuscript: Chemogenomic profiling predicts antifungal synergies (PDF, 1.5 MiB)
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| DOI | Resolve DOI: https://doi.org/10.1038/msb.2009.95 |
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| Author | Search for: Jansen, Gregor; Search for: Lee, Anna Y.; Search for: Epp, Elias1; Search for: Fredette, Amélie; Search for: Surprenant, Jamie; Search for: Harcus, Doreen1; Search for: Scott, Michelle; Search for: Tan, Elaine; Search for: Nishimura, Tamiko; Search for: Whiteway, Malcolm1; Search for: Hallett, Michael; Search for: Thomas, David Y. |
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| Affiliation | - National Research Council of Canada. NRC Biotechnology Research Institute
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| Format | Text, Article |
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| Subject | antifungal; chemical genomics; drug profiling; synergy predictor |
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| Abstract | Chemotherapies, HIV infections, and treatments to block organ transplant rejection are creating a population of immunocompromised individuals at serious risk of systemic fungal infections. Since single-agent therapies are susceptible to failure due to either inherent or acquired resistance, alternative therapeutic approaches such as multi-agent therapies are needed. We have developed a bioinformatics-driven approach that efficiently predicts compound synergy for such combinatorial therapies. The approach uses chemogenomic profiles in order to identify compound profiles that have a statistically significant degree of similarity to a fluconazole profile. The compounds identified were then experimentally verified to be synergistic with fluconazole and with each other, in both Saccharomyces cerevisiae and the fungal pathogen Candida albicans. Our method is therefore capable of accurately predicting compound synergy to aid the development of combinatorial antifungal therapies. |
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| Publication date | 2009-12-22 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | NRCC 49513 |
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| NPARC number | 18397755 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | a46c37fc-6d2f-4310-baa3-b7863cb0ecd0 |
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| Record created | 2012-03-06 |
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| Record modified | 2020-04-16 |
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