Antifungal Activity of Alkaloids from the Seeds of Chimonanthus praecox

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Download	View accepted manuscript: Antifungal Activity of Alkaloids from the Seeds of Chimonanthus praecox (PDF, 553 KiB)
DOI	Resolve DOI: https://doi.org/10.1002/cbdv.200800089
Author	Search for: Zhang, Ji-Wen; Search for: Gao, Jin-Ming¹; Search for: Xu, Tian; Search for: Zhang, Xing-Chang; Search for: Ma, Ya-Tuan¹; Search for: Jarussophon, Suwatchai¹; Search for: Konishi, Yasuo¹
Affiliation	National Research Council of Canada. NRC Biotechnology Research Institute
Format	Text, Article
Subject	activity; Antifungal Agents; Calycanthaceae; chemistry; drug effects; Fungi; In Vitro; Indoles; isolation & purification; Microbial Sensitivity Tests; Naphthyridines; pharmaceutical; pharmacology; Pyrroles; Seeds; Vitr
Abstract	Two alkaloids, d-calycanthine (1) and l-folicanthine (2), were isolated from the active MeOH extract of the seeds of Chimonanthus praecox Link. The structures of the two compounds were established by 1H- and 13C-NMR, and MS (FAB, ESI) analyses. In the in vitro tests, compounds 1 and 2 showed significant inhibitory activities against five plant pathogenic fungi Exserohilum turcicum, Bipolaris maydis, Alternaria solani, Sclerotinia sderotiorum, and Fusarium oxysportium, among which B. maydis was found to be the most susceptible to 1 with an EC50 value of 29.3 mg/ml, followed by S. sderotiorum to 2 with an EC50 value of 61.2 mg/ml. To our knowledge, this is the first report of isolation and LC/MS/MS identification as well as of antifungal properties of these alkaloids from the seeds of this plant.
Publication date	2009
In	CHEMISTRY & BIODIVERSITY 6, no. 6 (2009): 838–845.
Language	English
NRC number	NRCC 50672
NPARC number	12907843
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Record identifier	a52dc492-804a-4627-a301-c4eaeb1cd2ea
Record created	2009-11-10
Record modified	2020-04-16

Date modified:: 2024-07-01