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Identification of domoic acid, a neuroexcitatory amino acid found in toxic mussels from eastern Prince Edward Island

From National Research Council Canada

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Affiliation
  1. National Research Council of Canada
  2. National Research Council of Canada. NRC Canada Institute for Scientific and Technical Information
FormatText, Article
Abstract
The causative agent of toxicity in cultured mussels from a localized area of eastern Prince Edward Island has been identified as domoic acid, a neuroexcitatory amino acid. The toxin was isolated by a number of different bioassay-directed separation techniques including high-performance liquid chromatography, high-voltage paper electrophoresis, and ion-exchange chromatography, and characterized by a number of spectroscopic techniques including ultraviolet, infrared, mass spectrometry, and nuclear magnetic resonance. The isolation and purification methods are described in detail and some new analytical data for domoic acid are reported. Keywords: shellfish toxin, domoic acid, neurotoxin, bioassay-directed analysis.
Publication date
In
  • Canadian Journal of Chemistry 67, no. 3 (March 1989): 481–490.
LanguageEnglish
NRC numberWRIGHT1989
29840
NPARC number9380293
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Record identifiera822d8a5-fa94-4ff3-bfd2-2705e9ac50a4
Record created2009-07-10
Record modified2020-03-17
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