| Download | - View accepted manuscript: Isolation and synthetic diversification of jadomycin 4-amino-l-phenylalanine (PDF, 730 KiB)
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| DOI | Resolve DOI: https://doi.org/10.1021/np5009398 |
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| Author | Search for: Martinez-Farina, Camilo F.; Search for: Robertson, Andrew W.; Search for: Yin, Huimin; Search for: Monro, Susan; Search for: McFarland, Sherri A.; Search for: Syvitski, Raymond T.1; Search for: Jakeman, David L. |
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| Affiliation | - National Research Council of Canada. Aquatic and Crop Resource Development
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| Format | Text, Article |
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| ISSN | 0163-3864 |
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| Abstract | Streptomyces venezuelae ISP5230 was grown in the presence of phenylalanine analogues to observe whether they could be incorporated into novel jadomycin structures. It was found that the bacteria successfully produced jadomycins incorporating 4-aminophenylalanine enantiomers. Upon isolation and characterization of jadomycin 4-amino-l-phenylalanine (1), it was synthetically derivatized, using activated succinimidyl esters, to yield a small jadomycin amide library. These are the first examples of oxazolone-ring-containing jadomycins that have incorporated an amino functionality subsequently used for derivatization. |
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| Publication date | 2015-06-02 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | NRCC 56153 |
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| NPARC number | 21275909 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | b235da6e-490d-4cd7-9675-50572f95f5bc |
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| Record created | 2015-07-31 |
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| Record modified | 2020-06-04 |
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