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Constituents of the Vietnamese medicinal plant Orthosiphon stamineus.

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1248/cpb.48.1711
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FormatText, Article
SubjectOrthosiphon stamineus; staminane-type diterpene; Vietnamese medicinal plant; isopimarane-type diterpene; cytotoxicity; colon 26-L5 carcinoma
Abstract
From the MeOH extract of the aerial part of Vietnamese Orthosiphon stamineus, five new isopimarane-type diterpenes [orthosiphols F-J (1-5)] and two new diterpenes [staminols A (6) and B (7)] with a novel carbon-framework, to which we proposed the name "staminane", and three new highly-oxygenated staminane-type diterpenes [staminolactones A (8) and B (9) and norstaminol A (10)] were isolated. Moreover, staminolactone A (8) is 8, 14-secostaminane-type and staminolactone B (9) is 13, 14-secostaminane-type, while norstaminol A (10) is 14-norstaminen-type. Together with these new diterpenes, sixteen known compounds were also isolated and identified to be : 7, 3', 4'-tri-O-methylluteolin (11), eupatorin (12), sinensetin (13), 5-hydroxy-6, 7, 3'4'-tetramethoxyflavone (14), salvigenin (15), ladanein (16), tetramethylscutellarein (17), 6-hydroxy-5, 7, 4'-trimethoxyflavone (18), vomifoliol (19), aurantiamide acetate (20), rosmarinic acid (21), caffeic acid (22), oleanolic acid (23), ursolic acid (24), betulinic acid (25), and β-sitosterol (26). All the isolated compounds were tested for their cytotoxicity towards highly liver metastatic murine colon 26-L5 carcinoma cells, and the new diterpenes, except for 4, and flavonoids (11, 12, 16, 18) showed cytotoxicity with an ED^50 value between 10 and 90 μg/ml.
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  • Chemical and Pharmaceutical Bulletin 48, no. 11 (1 November 2000): 1711–1719.
LanguageEnglish
Peer reviewedYes
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NPARC number21275296
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Record created2015-06-02
Record modified2020-03-26
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