| Download | - View full text: Collateral circulation formation determines the characteristic profiles of contrast-enhanced MRI in the infarcted myocardium of pigs (PDF, 2 MB)
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| DOI | Resolve DOI: https://doi.org/10.1038/aps.2014.158 |
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| Author | Search for: Wang, Jian1 ; Search for: Xiang, Bo1 ; Search for: Lin, Hung-yu1 ; Search for: Liu, Hong-yu; Search for: Freed, Darren1 ; Search for: Arora, Rakesh C.1 ; Search for: Tian, Gang-hong1 |
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| Name affiliation | - National Research Council Canada. Medical Devices
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| Format | Text |
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| Type | Article |
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| Journal title | Acta Pharmacologica Sinica |
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| ISSN | 1671-4083
1745-7254 |
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| Volume | 36 |
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| Issue | 4 |
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| Pages | 463–472 |
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| Subject | myocardial infarction; myocardial reperfusion; contrast media; magnetic resonance imaging; gadolinium DTPA; coronary circulation; pigs; time factors |
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| Abstract | Aim: To investigate the relationship between the collateral circulation and contrast-enhanced MR signal change for myocardial infarction (MI) in pigs. Methods: Pigs underwent permanent ligation of two diagonal branches of the left anterior descending artery. First-pass perfusion (FPP) MRI (for detecting myocardial perfusion abnormalities) and delayed enhancement (DE) MRI (for estimating myocardial infarction) using Gd-DTPA were performed at 2 h, 7 d and 4 weeks after the coronary occlusion. Myocardial blood flow (MBF) was evaluated using nonradioactive red-colored microspheres. Histological examination was performed to characterize the infarcts. Results: Acute MI performed at 2 h afterwards was characterized by hypoenhancement in both FPP- and DE-MRI, with small and almost unchanged FPP-signal intensity (SI) and DE-SI due to negligible MBF. Subacute MI detected 7 d afterwards showed small but significantly increaseing FPP-SI, and was visible as a sluggish hyperenhancement in DE-MRI with considerably higher DE-SI compared to the normal myocardium; the MBF approached the half-normal value. Chronic MI detected at 4 weeks afterwards showed increasing FPP-SI comparable to the normal myocardium, and a rapid hyperenhancement in DE-MRI with even higher DE-SI; the MBF was close to the normal value. The MBF was correlated with FPP-SI (r=+0.94, P<0.01) and with the peak DE-SI (r=+0.92, P<0.01) at the three MI stages. Remodeled vessels were observed at intra-infarction and peri-infarction zones during the subacute and chronic periods. Conclusion: Progressive collateral recovery determines the characteristic profiles of contrast-enhanced MRI in acute, subacute and chronic myocardial infarction in pigs. The FPP- and DE-MRI signal profiles not only depend on the loss of tissue viability and enlarged interstitial space, but also on establishing a collateral circulation. |
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| Publication date | 2015-03-23 |
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| Terms of use | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 23000727 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction |
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Record identifier | b5bc6352-61b9-48f9-b739-3620b62332a3 | | Record created | 2016-09-01 |
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| Record modified | 2019-03-08 |
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