| DOI | Resolve DOI: https://doi.org/10.1364/BOE.4.001051 |
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| Author | Search for: Watts, B.R.; Search for: Zhang, Z.1; Search for: Xu, C.-Q.; Search for: Cao, X.; Search for: Lin, M. |
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| Affiliation | - National Research Council of Canada
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| Format | Text, Article |
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| Subject | Design modifications; False positive rates; Forward scatters; Integrated device; Integrated microfluidic devices; Optimal excitation; Polystyrene beads; Side scatter signal; Geometry; Photoexcitation; Polystyrenes; Signal detection; device fabrication; device testing; experimental design; fluorescence imaging; free space detection; laboratory diagnosis; light scattering; limit of detection; microfluidic analysis; optical excitation; optics; scatter detection |
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| Abstract | A photonic integrated microfluidic device is demonstrated to perform optical excitation and forward scatter collection all on-chip in a planar format. Integrated on-chip optics formed a tailored beam geometry for optimal excitation of particles while a special design modification allowed for on-chip forward collection with the beam shaping capabilities. A notch was placed in the lens system that caused a dark spot on the facet of a collection waveguide while not affecting the beam geometry at the point of interrogation. The modified device with the ability to form a 10 μm beam geometry was demonstrated to detect the forward scatter from blank 5 μm diameter polystyrene beads. Free-space collection of side scatter signals was performed simultaneously with the on-chip collection and the designs demonstrated and enhanced SNR while the reliability of detection was determined to be appropriate for many applications. Excellent performance was confirmed via a false positive rate of 0.4%, a missed events rate of 6.8%, and a coincident rate of 96.3% as determined between simultaneously performed free-space and on-chip detection schemes. © 2013 Optical Society of America. |
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| Publication date | 2013 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21270547 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | b60201b1-f4c3-46bb-a8e9-c184a1b35768 |
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| Record created | 2014-02-17 |
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| Record modified | 2020-04-22 |
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