| DOI | Resolve DOI: https://doi.org/10.1016/0960-894X(96)00092-3 |
|---|
| Author | Search for: Schneider, H.1; Search for: Fiander, H.1; Search for: Harrison, K.A.2; Search for: Watson, M.2; Search for: Burton, G. W.2; Search for: Arya, P.2 |
|---|
| Affiliation | - National Research Council of Canada. NRC Institute for Biological Sciences
- National Research Council of Canada. NRC Steacie Institute for Molecular Sciences
|
|---|
| Format | Text, Article |
|---|
| Abstract | The effectiveness of analogs of lithocholic acid and other bile acids in inhibiting glucuronosyltransferase activity in a colon cancer cell line was measured in order to identify structural features critical for inhibition of the enzyme. Analogs of lithocholic acid with modifications of the side chain (2-7) were synthesized, in part, to study their inhibitory effects on glucuronosyltransferase activity. Bishomolithocholic acid (4) was synthesized from the iodo derivative (9) by a free radical Michael type reaction using tris(trimethylsilyl)silane as a free radical mediator. The effectiveness of analogs of lithocholic acid and other bile acids on glucuronosyltransferase activity in a colon cancer cell line was measured in order to identify structural features critical for the inhibition. Analogs of lithocholic acid (2-7) were synthesized with modifications of the side chain. Bishomolithocholic acid (4) was synthesized from the iodo derivative (9) by a free radical Michael type reaction-using tris(trimethylsilyl)silane as a free radical mediator. |
|---|
| Publication date | 1996-03-19 |
|---|
| In | |
|---|
| Language | English |
|---|
| NRC number | SCHNEIDER1996 |
|---|
| NPARC number | 12338704 |
|---|
| Export citation | Export as RIS |
|---|
| Report a correction | Report a correction (opens in a new tab) |
|---|
| Record identifier | bc7177ba-b4fa-4a7e-b561-457c83bc8a42 |
|---|
| Record created | 2009-09-10 |
|---|
| Record modified | 2020-03-20 |
|---|
