| Download | - View final version: Phenotypic characterization of gamma delta (γδ) T cells in chickens infected with or vaccinated against Marek's disease virus (PDF, 3.3 MiB)
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| DOI | Resolve DOI: https://doi.org/10.1016/j.virol.2022.01.012 |
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| Author | Search for: Matsuyama-Kato, Ayumi; Search for: Iseki, Hiroshi; Search for: Boodhoo, Nitish; Search for: Bavananthasivam, Jegarubee1; Search for: Alqazlan, Nadiyah; Search for: Abdul-Careem, Mohamed Faizal; Search for: Plattner, Brandon L.; Search for: Behboudi, Shahriar; Search for: Sharif, ShayanORCID identifier: https://orcid.org/0000-0002-3158-012X |
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| Affiliation | - National Research Council of Canada. Human Health Therapeutics
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| Funder | Search for: Pirbright Institute; Search for: Natural Sciences and Engineering Research Council of Canada; Search for: Ontario Ministry of Agriculture, Food and Rural Affairs; Search for: UK Research and Innovation; Search for: Biotechnology and Biological Sciences Research Council |
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| Format | Text, Article |
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| Subject | Marek’s disease virus; vaccine; aerosol infection; chicken; γδ T cell; cytokine; cytotoxicity |
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| Abstract | Marek’s disease (MD) vaccines reduce the incidence of MD but cannot control virus shedding. To develop new vaccines, it is essential to elucidate mechanisms of immunity to Marek’s disease virus (MDV) infection. In this regard, gamma delta (γδ) T cells may play a significant role in prevention of viral spread and tumor surveillance. Here we demonstrated that MDV vaccination induced interferon (IFN)-γ⁺CD8α⁺ γδ T cells and transforming growth factor (TGF)-β⁺ γδ T cells in lungs. γδ T cells from MDV-infected chickens exhibited cytotoxic activity. Importantly, γδ T cells from the vaccinated/challenged group exhibited maximum cytotoxic activity following ex vivo stimulation. These results suggest that MDV vaccines activate effector γδ T cells which may be involved in the development of protective immune responses against MD. Further, it was demonstrated that MDV infection increases the frequency of a subpopulation of γδ T cells expressing membrane-bound TGF-β in MDV-infected birds. |
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| Publication date | 2022-01-25 |
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| Publisher | Elsevier |
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| Licence | |
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| Language | English |
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| Peer reviewed | Yes |
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| Identifier | S0042682222000198 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | bf17df90-fb7e-4ef5-97d9-6bb95901427c |
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| Record created | 2024-02-19 |
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| Record modified | 2024-02-19 |
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