| DOI | Resolve DOI: https://doi.org/10.1016/j.tig.2007-04-003 |
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| Author | Search for: Cui, Qinghua1; Search for: Yu, Zhenbao1; Search for: Purisima, Enrico O.1; Search for: Wang, Edwin1 |
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| Affiliation | - National Research Council of Canada. NRC Biotechnology Research Institute
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| Format | Text, Article |
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| Subject | biotechnology; gene expression; genes; genome; pharmaceutical |
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| Abstract | MicroRNAs (miRNAs) modulate expression of their target genes in various tissues and at different developmental stages, but it is unclear whether they drive cross-species variation in gene expression. By comparing data from mammal and fly species we found that the cross-species expression variation of miRNA targets is significantly lower than that of other genes. This implies that miRNAs can affect gene expression by reducing stochastic noise, buffering cross-species variation and constraining evolutionary gene expression variation |
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| Publication date | 2007 |
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| In | |
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| Language | English |
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| NRC number | 47563 |
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| NPARC number | 3539530 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | c1a3a3b5-f404-4fbb-adaf-cc0a23243480 |
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| Record created | 2009-03-01 |
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| Record modified | 2020-05-10 |
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