| DOI | Resolve DOI: https://doi.org/10.1016/j.jneumeth.2011.10.030 |
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| Author | Search for: Blasiak, Barbara; Search for: Volotovskyy, Vyacheslav1; Search for: Deng, Charlie; Search for: Foniok, Tadeusz; Search for: Tomanek, Boguslaw1 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Biodiagnostics
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| Format | Text, Article |
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| Subject | MRI; Glioma; Brain; Low field MRI; RF coil |
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| Abstract | Both 0.2 T and 9.4 T MRI systems were used to image a mouse model of glioma. RF coils were designed for both fields. A spin-echo, multi-echo pulse sequence was used to determine T2 relaxation times of both brain and tumor tissues. Contrast-to-noise ratio was calculated based on the selected echo time. The results showed that 0.2 T is suitable for mouse model imaging, however total scan time must be long to achieve high enough SNR. T2 relaxation times of the tumor and brain tissues can be measured at 0.2 T and are 2.1 and 1.8 times respectively longer at 0.2 T than at 9.4 T. Contrast to noise ratio for tumor and brain was better at high field than at the low field. We concluded that 0.2 T may be used to study mouse model of glioma using spin echo pulse sequence, yet the total scan time is long (about 40 min), resolution is lower (∼250 μm × 250 μm) and slice thickness (3 mm) must be large enough to obtain sufficient SNR. |
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| Publication date | 2012-02-15 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| Identifier | S016502701100656X |
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| NPARC number | 21268793 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | c26b08d9-0eaf-41e2-9620-d1f05e2667ca |
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| Record created | 2013-11-13 |
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| Record modified | 2020-04-21 |
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