| Download | - View accepted manuscript: Association of anti-GT1a antibodies with an outbreak of Guillain-Barré syndrome and analysis of ganglioside mimicry in an associated Campylobacter jejuni strain (PDF, 667 KiB)
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| DOI | Resolve DOI: https://doi.org/10.1371/journal.pone.0131730 |
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| Author | Search for: Zhang, Maojun; Search for: Gilbert, Michel1; Search for: Yuki, Nobuhiro; Search for: Cao, Fangfang; Search for: Li, Jianjun1; Search for: Liu, Hongying; Search for: Li, Qun; Search for: Meng, Fanliang; Search for: Zhang, Jianzhong |
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| Affiliation | - National Research Council of Canada. Human Health Therapeutics
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| Format | Text, Article |
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| Subject | anti-ganglioside antibody; phylogenetic analysis; antigenic drift; ganglioside antibody; ganglioside GD 1b; ganglioside GD3; ganglioside GM1; ganglioside GM2; ganglioside GQ 1b; ganglioside GT 1a; glycosyltransferase; immunoglobulin G antibody; immunoglobulin M antibody; lipooligosaccharide; antibody blood level; bacterial genome; bacterial strain; cgtA gene; cgtB gene; cst II gene; diarrhea; DNA sequence; gastroenteritis; molecular mimicry; phylogenetic tree; phylogeny; single nucleotide polymorphism |
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| Abstract | An outbreak of Guillain-Barré syndrome (GBS), subsequent to Campylobacter jejuni enteritis, occurred in China in 2007. Serum anti-ganglioside antibodies were measured in GBS patients and controls. Genome sequencing was used to determine the phylogenetic relationship among three C. jejuni strains from a patient with GBS (ICDCCJ07001), a patient with gastroenteritis (ICDCCJ07002) and a healthy carrier (ICDCCJ07004), which were all associated with the outbreak. The ganglioside-like structures of the lipo-oligosaccharides of these strains were determined by mass spectrometry. Seventeen (53%) of the GBS patients had anti-GT1a IgG antibodies. GT1a mimicry was found in the lipo-oligosaccharides of strain ICDCCJ07002 and ICDCCJ07004; but a combination of GM3/GD3 mimics was observed in ICDCCJ07001, although this patient had anti-GT1a IgG antibodies. A single-base deletion in a glycosyltransferase gene caused the absence of GT1a mimicry in ICDCCJ07001. The phylogenetic tree showed that ICDCCJ07002 and ICDCCJ07004 were genetically closer to each other than to ICDCCJ07001. C. jejuni, bearing a GT1a-like lipo-oligosaccharide, might have caused the GBS outbreak and the loss of GT1a mimicry may have helped ICDCCJ07001 to survive in the host. |
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| Publication date | 2015-07-21 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | NRC-HHT-53231 |
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| NPARC number | 21275343 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | c29b6749-3a3c-4e6d-85b8-81bc3b0df95c |
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| Record created | 2015-06-15 |
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| Record modified | 2020-06-04 |
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