Development of an anti-vascular cell adhesion protein-1 aptamer for molecular imaging and inflammation detection in transgenic mouse model of Alzheimer's disease

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  1. National Research Council of Canada. Human Health Therapeutics
FormatText, Article
Subjectcell adhesion; cell; cytology; diagnosis; dissociation; endothelial cells; infrared devices; mammals; molecules; neurodegenerative diseases; pathology; Alzheimer's disease; aptamers; near-infrared fluorescence imaging; therapeutic monitoring; vascular cell adhesion; vcam-1; molecular imaging; amyloid beta protein; aptamer; cyanine dye 5 11R6; fluorescein; fluorescent dye; single stranded DNA; vascular cell adhesion molecule 1; animal experiment; animal model; animal tissue; cerebellum; DNA library; DNA sequence; electrophoretic mobility; fluorescence imaging; fluorescence microscopy; gel mobility shift assay; human cell; in vitro selection; In vivo study; mouse; nervous system inflammation; protein targeting; umbilical vein endothelial cell; disease model; fluorescence imaging; genetics; inflammation; metabolism; molecular imaging; nucleotide sequence; transgenic mouse; aptamers, nucleotide; base sequence; disease models, animal; human umbilical vein endothelial cells; inflammation; mice, transgenic; optical imaging
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NPARC number21277338
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Record identifierc5414c9b-5302-4caa-a514-b2759c8ba8a1
Record created2016-03-09
Record modified2020-04-22
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