| DOI | Resolve DOI: https://doi.org/10.1016/j.carres.2018.04.010 |
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| Author | Search for: Vinogradov, Evgeny1; Search for: St Michael, Frank1; Search for: Cox, Andrew D.1 |
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| Affiliation | - National Research Council of Canada. Human Health Therapeutics
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| Format | Text, Article |
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| Subject | Fusobacterium nucleatum; lipopolysaccharide; NMR spectroscopy; polysaccharide; structure |
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| Abstract | Fusobacterium nucleatum is an anaerobic bacterium found in the human mouth where it causes periodontitis. It was also found in colorectal cancer tissues and is linked with pregnancy complications, including pre-term and still births. Cell surface structures of the bacterium could be implicated in pathogenesis. Here we report the following structure of the lipopolysaccharide O-chain of F. nucleatum strain MJR 7757 B:where Lac is (R)-1-carboxyethyl (lactic acid residue); all monosaccharides are in the pyranose form. ManNAc4Lac, analogue of N-acetylmuramic acid, is found for the first time in natural sources. |
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| Publication date | 2018-04-25 |
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| Publisher | Elsevier |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 23003953 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | c6a6dfe6-d346-404b-a26b-000ac8083ea8 |
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| Record created | 2018-08-24 |
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| Record modified | 2020-03-16 |
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