| DOI | Resolve DOI: https://doi.org/10.1016/j.carbpol.2022.120108 |
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| Author | Search for: Hrapovic, Sabahudin1; Search for: Martinez-Farina, Camilo F.1; Search for: Sui, Jessie; Search for: Lavertu, Jean-Danick1; Search for: Hemraz, Usha D.1 |
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| Affiliation | - National Research Council of Canada. Aquatic and Crop Resource Development
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| Funder | Search for: National Research Council of Canada |
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| Format | Text, Article |
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| Subject | chitosan nanocrystals; amino acids; peptides; nanomaterials; solid phase synthesis |
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| Abstract | Antimicrobial peptides (AMPs) offer a great promise in designing new therapeutics due to their ability to interfere in bacterial growth by penetrating the cell wall. The overuse of antibiotics has resulted into antibiotic-resistant bacteria and AMPs could be an alternative to circumvent this resistance. Chitosan nanocrystals (ChsNCs) are rod-shaped polysaccharide-based nanomaterials, formed by deacetylation of seafood waste. They possess primary amino groups on the surface of the nanoparticles which can be as used a scaffold due to the built-in morphology and ease in functionalization. Here, we developed a new methodology to functionalize ChsNCs with amino acids and peptides by using fundamentals of solid phase peptide synthesis. The resulting functionalized rod-shaped nanomaterials were characterized using nuclear magnetic resonance (NMR), dynamic light scattering (DLS), zeta potential measurements and microscopy imaging. This synthetic strategy could be used in designing ChsNC-based nanomaterials to target specific cells by attaching bioactive peptides to the nanomaterial surface. |
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| Publication date | 2022-09-15 |
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| Publisher | Elsevier |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| Identifier | S014486172201013X |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | c86fdfb3-bedc-4328-af49-c2bd5ca7b023 |
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| Record created | 2022-12-02 |
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| Record modified | 2023-03-16 |
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