Enantioselective Esterification of Racemic Ibuprofen in Solvent Media under Reduced Pressure

DOI	Resolve DOI: https://doi.org/10.1002/(SICI)1097-4660(199706)69:2<266::AID-JCTB698>3.0.CO;2-6
Author	Search for: Roure, Frederic; Search for: Ducret, Amélie¹; Search for: Trani, Michael¹; Search for: Lortie, Robert¹
Affiliation	National Research Council Canada. NRC Biotechnology Research Institute
Format	Text, Article
Abstract	The enantioselective esterification of (R,S)-ibuprofen has been performed with Novozym 435TM in solvent media under reduced pressure. The nature of the solvent affects the activity and enantioselectivity of the lipase. High esterification rates are obtained in solvents having high hydrophobicity (log P>4). On the other hand, the best enantioselectivity is obtained with solvents having low hydrophobicity (log P<3). This particular enantioselectivity trend is observed within the individual solvent families investigated (alkanes, ethers and aromatics). � Canadian Crown Copyright 1997
Publication date	1997
In	Journal of Chemical Technology & Biotechnology 69, no. 2 (1997): 266–270.
NPARC number	12327710
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Record identifier	ca51be83-23df-4cd2-a8f6-7094529123a7
Record created	2009-09-10
Record modified	2020-03-20

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