| DOI | Resolve DOI: https://doi.org/10.1016/0005-2736(87)90413-5 |
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| Author | Search for: Surewicz, W. K.1; Search for: Epand, R. M.; Search for: Orlowski, R. C.; Search for: Mantsch, H. H.1 |
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| Affiliation | - National Research Council of Canada
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| Format | Text, Article |
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| Subject | Calcitonin; Lipid-protein interaction; Phospholipid structure; Fourier transform infrared spectroscopy |
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| Abstract | The interaction of the polypeptide hormone calcitonin with two acidic phospholipids, dimyristoylphosphatidylglycerol (DMPG) and dimyristoylphosphatidic acid (DMPA), was investigated by Fourier-transform infrared spectroscopy. The association of calcitonin with DMPG results in a broadening of the lipid phase transition, accompanied by a marked decrease in the conformational order of the acyl chains at temperatures below the phase transition region. Infrared bands due to carbonyl ester and phosphate group vibrations of DMPG molecules are not significantly affected by the presence of calcitonin. The effect of calcitonin on the conformation of acyl chains in DMPA is much smaller compared with DMPG. The different susceptibility of DMPG and DMPA to perturbation by calcitonin is suggested to be related to different degrees of intermolecular interactions between the headgroups of these two phospholipids. |
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| Publication date | 1987-05-29 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 23001258 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | ca8a8629-8f5c-458d-a32c-2fe568a879a6 |
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| Record created | 2017-01-12 |
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| Record modified | 2020-03-17 |
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