| DOI | Resolve DOI: https://doi.org/10.1016/j.biotechadv.2008.10.003 |
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| Author | Search for: Dormond, E.1; Search for: Perrier, M.; Search for: Kamen, A.1 |
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| Affiliation | - National Research Council of Canada. NRC Biotechnology Research Institute
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| Format | Text, Article |
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| Subject | biotechnology; cell culture; gene therapy; therapy; adenovirus; helper-dependent adenoviral vector; production; quantification |
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| Abstract | Human adenoviral viral vector serotype 5 (AdV) is presently the primary viral vector used in gene therapy trials. Advancements in AdV process development directly contribute to the clinical application and commercialization of the AdV gene delivery technology. Notably, the development of AdV production in suspension culture has driven the increase in AdV volumetric and specific productivity, therefore providing large quantities of AdV required for clinical studies. This review focuses on detailing the viral, cell and cell culture parameters governing the productivity of the three generations of AdV vectors. |
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| Publication date | 2008-10-31 |
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| In | |
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| Language | English |
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| NRC number | NRCC 47833 |
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| NPARC number | 12390838 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | cbc7bc8a-f1be-4037-85a2-bf93bcc62815 |
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| Record created | 2009-10-26 |
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| Record modified | 2020-04-15 |
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