| Download | - View final version: Terrosamycins A and B, bioactive polyether ionophores from Streptomyces sp. RKND004 from Prince Edward Island sediment (PDF, 940 KiB)
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| DOI | Resolve DOI: https://doi.org/10.3390/md17060347 |
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| Author | Search for: Sproule, Amanda; Search for: Correa, Hebelin; Search for: Decken, Andreas; Search for: Haltli, Bradley; Search for: Berrué, Fabrice1; Search for: Overy, David P.; Search for: Kerr, Russell G. |
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| Affiliation | - National Research Council of Canada. Aquatic and Crop Resource Development
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| Format | Text, Article |
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| Subject | Streptomyces; X-ray diffraction; antibiotic; marine sediment; metabolomics; polycyclic polyether |
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| Abstract | Terrosamycins A (1) and B (2), two polycyclic polyether natural products, were purified from the fermentation broth of Streptomyces sp. RKND004 isolated from Prince Edward Island sediment. The one strain-many compounds (OSMAC) approach coupled with UPLC-HRMS-based metabolomics screening led to the identification of these compounds. The structure of 1 was determined from analysis of NMR, HRMS, and X-ray diffraction data. NMR experiments performed on 2 revealed the presence of two methoxy groups replacing two hydroxy groups in 1. Like other polyether ionophores, 1 and 2 exhibited excellent antibiotic activity against Gram-positive pathogens. Interestingly, the terrosamycins also exhibited activity against two breast cancer cell lines. |
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| Publication date | 2019-06-11 |
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| Publisher | MDPI |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | NRC-ACRD-PDB006 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | cd05e796-70c0-4077-a28b-b1faca811c14 |
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| Record created | 2019-07-09 |
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| Record modified | 2020-05-30 |
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