| DOI | Resolve DOI: https://doi.org/10.1016/j.yexcr.2017.05.003 |
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| Author | Search for: Xie, Dongxue; Search for: Liu, Zhonghui; Search for: Wu, Jiandong; Search for: Feng, Wenfang; Search for: Yang, Ke; Search for: Deng, Jixian1; Search for: Tian, Ganghong1; Search for: Santos, Susy; Search for: Cui, Xueling; Search for: Lin, Francis |
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| Affiliation | - National Research Council of Canada. Medical Devices
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| Format | Text, Article |
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| Subject | activin A; breast cancer cells; neutrophils; migration; microfluidic device |
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| Abstract | Activin A belongs to the superfamily of transforming growth factor beta (TGFβ) and is a critical regulatory cytokine in breast cancer and inflammation. However, the role of activin A in migration of breast cancer cells and immune cells was not well characterized. Here, a microfluidic device was used to examine the effect of activin A on the migration of human breast cancer cell line MDA-MB-231 cells and human blood neutrophils as well as their migratory interaction. We found that activin A promoted the basal migration but impaired epidermal growth factor (EGF)-induced migration of breast cancer cells. By contrast, activin A reduced neutrophil chemotaxis and transendothelial migration to N-Formyl-Met-Leu-Phe (fMLP). Finally, activin A promoted neutrophil chemotaxis to the supernatant from breast cancer cell culture. Collectively, our study revealed the different roles of activin A in regulating the migration of breast cancer cells and neutrophils and their migratory interaction. These findings suggested the potential of activin A as a therapeutic target for inflammation and breast cancers. |
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| Publication date | 2017-05-04 |
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| Publisher | Elsevier |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 23003356 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | d3185cbc-373b-4dce-9350-d511584157e1 |
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| Record created | 2018-05-22 |
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| Record modified | 2020-03-16 |
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