| Download | - View final version: Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection (PDF, 3.1 MiB)
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| DOI | Resolve DOI: https://doi.org/10.1038/s41598-021-90243-1 |
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| Author | Search for: Cuperlovic-Culf, Miroslava1; Search for: Cunningham, Emma L.; Search for: Teimoorinia, Hossen2; Search for: Surendra, Anuradha1; Search for: Pan, Xiaobei; Search for: Bennett, Steffany A. L.1; Search for: Jung, Mijin; Search for: McGuiness, Bernadette; Search for: Passmore, Anthony Peter; Search for: Beverland, David; Search for: Green, Brian D. |
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| Affiliation | - National Research Council of Canada. Digital Technologies
- National Research Council of Canada. Herzberg Astronomy and Astrophysics
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| Funder | Search for: National Research Council, Canada; Search for: Alzheimer’s Research UK |
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| Format | Text, Article |
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| Abstract | Delirium is an acute change in attention and cognition occurring in ~ 65% of severe SARS-CoV-2 cases. It is also common following surgery and an indicator of brain vulnerability and risk for the development of dementia. In this work we analyzed the underlying role of metabolism in delirium-susceptibility in the postoperative setting using metabolomic profiling of cerebrospinal fluid and blood taken from the same patients prior to planned orthopaedic surgery. Distance correlation analysis and Random Forest (RF) feature selection were used to determine changes in metabolic networks. We found significant concentration differences in several amino acids, acylcarnitines and polyamines linking delirium-prone patients to known factors in Alzheimer’s disease such as monoamine oxidase B (MAOB) protein. Subsequent computational structural comparison between MAOB and angiotensin converting enzyme 2 as well as protein–protein docking analysis showed that there potentially is strong binding of SARS-CoV-2 spike protein to MAOB. The possibility that SARS-CoV-2 influences MAOB activity leading to the observed neurological and platelet-based complications of SARS-CoV-2 infection requires further investigation. |
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| Publication date | 2021-05-20 |
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| Publisher | Springer Science and Business Media LLC |
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| Language | English |
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| Peer reviewed | Yes |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | d7c405c5-fa50-425b-a5bb-9ad16a3c2dc4 |
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| Record created | 2023-11-06 |
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| Record modified | 2023-11-06 |
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