| Download | - View accepted manuscript: Substance P primes lipoteichoic acid- and Pam3CysSerLys4- mediated activation of human mast cells by up-regulating Toll-like receptor 2 (PDF, 717 KiB)
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| DOI | Resolve DOI: https://doi.org/10.1111/j.1365-2567.2010.03296.x |
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| Author | Search for: Tancowny, Brian P.; Search for: Karpov, Victor; Search for: Schleimer, Robert P; Search for: Kulka, Marianna |
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| Format | Text, Article |
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| Subject | chemokines; immunoglobulin E; mast cells; neuropeptides; substance P; vasoactive intestinal peptide |
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| Abstract | Substance P (SP) is a neuropeptide with neuroimmunoregulatory activity that may play a role in susceptibility to infection. Human mast cells which are important in innate immune responses, were analysed for their responses to pathogen-associated molecules via Toll-like receptors (TLRs in the presence of SP. Human cultured mast cells (LAD2) were activated by SP and TLR ligands including lipopolysaccharide (LPS), Pam3CysSer- Lys4 (Pam3CSK4) and lipoteichoic acid (LTA), and mast cell leukotriene and chemokine production was assessed by enzyme-linked immunosorbent assay (ELISA) and gene expression by quantitative PCR (qPCR). |
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| Publication date | 2010-03-30 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 17326690 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | d96b6a23-eab8-424e-95e2-261355ff706a |
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| Record created | 2011-03-18 |
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| Record modified | 2020-04-17 |
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