| DOI | Resolve DOI: https://doi.org/10.1002/pmic.201500169 |
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| Author | Search for: Nasheri, Neda1; Search for: Ning, Zhibin; Search for: Figeys, Daniel; Search for: Yao, Shao; Search for: Goto, Natalie K.; Search for: Pezacki, John Paul2 |
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| Affiliation | - National Research Council of Canada
- National Research Council of Canada. Medical Devices
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| Format | Text, Article |
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| Subject | proteasome; ubiquitin; virus protein; chronic hepatitis C; down regulation; Hepatitis C virus; protein expression; protein subunit; quantitative analysis; virus replication |
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| Abstract | Hepatitis C virus (HCV) infection often leads to chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. The stability of the HCV proteins is controlled by ubiquitin-dependent and ubiquitin-independent proteasome pathways. Many viruses modulate proteasome function for their propagation. To examine the interrelationship between HCV and the proteasome pathways we employed a quantitative activity-based protein profiling method. Using this approach we were able to quantify the changes in the activity of several proteasome subunits and found that proteasome activity is drastically reduced by HCV replication. The results imply a link between the direct downregulation of the activity of this pathway and chronic HCV infection. |
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| Publication date | 2015-10-08 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21277371 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | da43b367-fe63-43ea-9274-105f77de416e |
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| Record created | 2016-03-09 |
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| Record modified | 2020-04-22 |
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