Ion-spray mass spectrometry of marine toxins II. Analysis of diarrhetic shellfish toxins in plankton by liquid chromatography/mass spectrometry

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1002/rcm.1290040608
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Name affiliation
  1. National Research Council of Canada. NRC Institute for Marine Biosciences
FormatText, Article
Journal titleRapid Communications in Mass Spectrometry
ISSN0951-4198
1097-0231
Volume4
Issue6
Pages206–213
Abstract
A combined liquid chromatography/mass spectrometry (LC/MS) method using ion-spray ionization is described for the sensitive determination of okadaic acid and dinophysistoxin-1, the principal toxins implicated in cases of diarrhetic shellfish poisoning. The method is used to confirm the presence of okadaic acid in a culture of the dinoflagellate species Prorocentrum concavum and in natural populations of dinoflagellates from eastern Canadian waters. Several analogues of the toxin have also been detected. Quantitative results are comparable to those obtained by high performance liquid chromatography with fluorescence detection. With slight modifications, the LC/MS method is also used to analyse the fluorescent anthrylmethyl ester of okadaic acid. Preliminary tandem mass spectrometric results, obtained using fast-atom bombardment ionization, are presented for okadaic acid.
Publication date
LanguageEnglish
Peer reviewedYes
NPARC number23001064
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