| Download | - View accepted manuscript: Cu2+-labeled, SPION loaded porous silica nonparticles for cell labeling and multifunctional imaging probes (PDF, 694 KiB)
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| DOI | Resolve DOI: https://doi.org/10.1016/j.biomaterials.2009.12.025 |
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| Author | Search for: Patel, Daksha1; Search for: Kell, Arnold1; Search for: Simard, Benoit1; Search for: Deng, Jixian2; Search for: Xiang, Bo2; Search for: Lin, Hung-Yu; Search for: Gruwel, Marco2; Search for: Tian, Ganghong2 |
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| Affiliation | - National Research Council of Canada. NRC Steacie Institute for Molecular Sciences
- National Research Council of Canada. NRC Institute for Biodiagnostics
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| Format | Text, Article |
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| Subject | Cell viability; Copper; Cytotoxicity; In vitro test; MRI (magnetic resonance imaging); Surface modification |
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| Abstract | We have developed an ion-sensing nanoparticle that is comprised of a superparamagnetic iron oxide (SPIO) core encapsulated with a porous silica shell. The latter can be readily anchored with ligands capable of coordinating with positron-emitting metal. Evidently, this nanoparticle has a great potential for use in cell tracking with magnetic resonance (MR) imaging and positron emission tomography (PET). Herein we report the synthesis, surface functionalization and characterization of the magnetic nanoparticle-based probes and evaluate their cell-labeling efficacy, cytoxicity and relaxivity in comparison to one of the most commonly utilized MRI contrast agents, Feridex®. |
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| Publication date | 2010-01-06 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 17653072 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | e1d02677-8763-4868-b90f-654c34307172 |
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| Record created | 2011-04-01 |
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| Record modified | 2020-04-17 |
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