Download | - View accepted manuscript: Prognosis of chronic lymphocytic leukemia from infrared spectra of lymphocytes (PDF, 789 KiB)
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DOI | Resolve DOI: https://doi.org/10.1016/S0022-2860(96)09462-8 |
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Author | Search for: Schultz, Christian P.1; Search for: Liu, Kan-Zhi1; Search for: Johnston, James B.; Search for: Mantsch, Henry H.1 |
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Affiliation | - National Research Council of Canada. NRC Institute for Biodiagnostics
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Format | Text, Article |
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Subject | chronic lymphocytic leukemia; infrared spectroscopy; linear discriminant analysis; DNA spectra |
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Abstract | Peripheral mononuclear cells obtained from blood of normal individuals and from patients with chronic lymphocytic leukemia (CLL) were investigated by infrared spectroscopy and multivariate statistical analysis. Not only are the spectra of CLL cells different from those of normal cells, but hierarchical clustering also separated the CLL cells into a number of subclusters, based on their different DNA content, a fact which may provide a useful diagnostic tool for staging (progression of the disease) and multiple clone detection. Moreover, there is evidence for a correlation between the increased amount of DNA in the CLL cells and the in-vivo doubling time of the lymphocytes in a given patient. |
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Publication date | 1997-06-01 |
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Terms of use | - You may reproduce (print, make photocopies, or download) the accepted manuscript without permission for non-commercial purposes (research, education, and private study), on the condition that you provide proper attribution of the source in all copies.
- Vous pouvez reproduire (imprimer, faire des photocopies ou télécharger) le manuscrit accepté sans autorisation à des fins non commerciales (recherche, éducation et études privées), à condition de fournir la source appropriée dans toutes les copies.
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Access condition | |
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In | |
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Language | English |
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Peer reviewed | Yes |
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NPARC number | 9201850 |
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Export citation | Export as RIS |
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Report a correction | Report a correction (opens in a new tab) |
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Record identifier | e1e75503-4c29-43d2-a09a-c63bc762fcce |
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Record created | 2009-10-03 |
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Record modified | 2020-03-20 |
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