microarray; gene analysis; gene selections; tumour classification; marker genes; tumour diagnostics; feature analysis; feature selection; analyse génétique; choix des gènes; classification des tumeurs; gènes marqueurs; diagnostic des tumeurs; analyse des caractéristiques; choix des caractéristiques
Cancer classification has traditionally been based on the morphological study of tumours. However, tumours with similar histological appearances can exhibit different responses to therapy, indicating differences in tumour characteristics on the molecular level. Thus, development of a novel, reliable and precise method for classification of tumours is essential for more successful diagnosis and treatment. The high-throughput gene expression data obtained using microarray technology are currently being investigated for diagnostic applications. However, these large datasets introduce a range of challenges, making data analysis a major part of every experiment for any application, including cancer classification and diagnosis. One of the major concerns in the application of microarrays to tumour diagnostics is the fact that the expression levels of many genes are not measurably affected by carcinogenic changes in the cells. Thus, a crucial step in the application of microarrays to cancer diagnostics is the selection of diagnostic marker genes from the gene expression profiles. These molecular markers give valuable additional information for tumour diagnosis, prognosis and therapy development.
Acoustics, Speech, and Signal Processing Newsletter, IEEE, no. 2005 (2005).