| DOI | Resolve DOI: https://doi.org/10.1002/nbm.4065 |
|---|
| Author | Search for: Mohajeri, Sanaz; Search for: Bezabeh, TedrosORCID identifier: https://orcid.org/0000-0002-6618-3124; Search for: Ijare, Omkar B.; Search for: King, Scott B.1; Search for: Thomas, Michael AlbertORCID identifier: https://orcid.org/0000-0001-9037-2585; Search for: Minuk, Gerald; Search for: Lipschitz, Jeremy; Search for: Kirkpatrick, Iain; Search for: Micflikier, Allan B.; Search for: Summers, Randy1; Search for: Smith, Ian C. P. |
|---|
| Affiliation | - National Research Council of Canada. Medical Devices
|
|---|
| Format | Text, Article |
|---|
| Subject | choline‐containing phospholipids; glycine‐conjugated bile acids; human bile; in vivo 1H MRS; L‐COSY; pathogenesis; primary sclerosing cholangitis; taurine‐conjugated bile acids |
|---|
| Abstract | Primary sclerosing cholangitis (PSC) has been considered to be either an “autoimmune disease” or a “bile acid‐induced injury.” In vitro MRS studies on PSC patients have limitations due to the contamination of bile with contrast agent (commonly administered during endoscopic retrograde cholangiopancreatography) and/or the use of patient cohorts with other diseases as controls. The objective of this study was to quantify biliary metabolites using in vivo 1H MRS and gain insight into the pathogenesis of PSC. Biliary metabolites in 10 PSC patients and 14 healthy controls were quantified in vivo using 1H MRS on a 3 T MR scanner. The concentrations of total bile acids plus cholesterol, glycine‐conjugated bile acids, taurine‐conjugated bile acids, and choline‐containing phospholipids (chol‐PLs) were compared between the two groups. There were statistically significant decreases in the levels of the above mentioned biliary metabolites in the PSC patients compared with controls. The reduction in bile acid secretion in bile of PSC patients indicates accumulation of bile acids in hepatocytes. Moreover, reduction in the levels of chol‐PLs in bile may increase the toxic effects of bile acids. Our findings suggest that the bile duct injury in PSC patients is most likely due to “bile acid‐induced injury.” |
|---|
| Publication date | 2019-02-08 |
|---|
| Publisher | Wiley |
|---|
| In | |
|---|
| Language | English |
|---|
| Export citation | Export as RIS |
|---|
| Report a correction | Report a correction (opens in a new tab) |
|---|
| Record identifier | e5a4c3b3-0a22-4735-a839-86881fdfafe4 |
|---|
| Record created | 2021-03-17 |
|---|
| Record modified | 2021-09-17 |
|---|
