Influence of water activity on the enantioselective esterification of (R,S)-ibuprofen by crosslinked crystals of <I>Candida antarctica</I> lipase B in organic solvent media

DOI	Resolve DOI: https://doi.org/10.1002/bit.10051
Author	Search for: Pepin, Pierre; Search for: Lortie, Robert¹
Affiliation	National Research Council Canada. NRC Biotechnology Research Institute
Format	Text, Article
Abstract	The lipase B from was purified from a commercial source and crystalized. The microcrystals were crosslinked using glutaraldehyde. The crosslinked crystals were then used to catalyze the esterification of ()-ibuprofen with dodecanol in octane at various water activities. As for the commercial preparation immobilized on acrylic resin, Novozym 435, low water activities foster better enantioselectivity, and the maximum reaction rates are obtained for W = 0.1. � 2001 John Wiley & Sons, Inc. Biotechnol Bioeng 75: 559-562, 2001.
Publication date	2001
In	Biotechnology and Bioengineering 75, no. 5 (2001): 559–562.
NPARC number	12327007
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Record identifier	e8be2d6d-d02b-403c-8e90-c0631d6890fa
Record created	2009-09-10
Record modified	2020-03-27