An antiproliferative norditerpene dilactone, Nagilactone C, from Podocarpus neriifolius

From National Research Council Canada

DOI	Resolve DOI: https://doi.org/10.1078/S0944-7113(04)70071-9
Author	Search for: Shrestha, K; Search for: Banskota, A. H.; Search for: Kodata, S.; Search for: Shrivastava, G.; Search for: Strobel, G.; Search for: Gewali, M. B.
Format	Text, Article
Subject	Podocarpus neriifolius; antiproliferative activity for cancer cells; norditerpene dilactone; nagilactone C
Abstract	An ethanolic extract of Podocarpus neriifolius D. Don (Podocarpaceae) showed antiproliferative activity against two major tumor cell lines, viz. human HT-1080 fibrosarcoma and murine color 26-L5 carcinoma. Bioassay guided fractionation showed the highest antiproliferative activity in chloroform–soluble fraction. Nagilactone C, the major constituent of this fraction was isolated and characterized by using NMR, IR and FAB-MS spectroscopic methods. Nagilactone C possessed potent antiproliferative activity against human fibrosarcoma and murine colon carcinoma tumor cell lines exhibiting ED50 values of 2.3 and 1.2 μg/ml, respectively. Hence, nagilactone C could be the active constituent present in this plant.
Publication date	2001-12-31
In	Phytomedicine 8, no. 6 (31 December 2001): 489–491.
Language	English
Peer reviewed	Yes
NRC publication	This is a non-NRC publication "Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.
NPARC number	21274802
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Record identifier	eba13dac-1189-4cce-ae12-f5348e2fcd97
Record created	2015-04-12
Record modified	2020-03-27

Date modified:: 2024-07-22