| Download | - View accepted manuscript: Predicting pharmaceutical manufacturing changes using molecular laser-induced breakdown spectroscopy and chemometrics (PDF, 157 KiB)
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| Author | Search for: Doucet, François R.1; Search for: Faustino, Patrick J.; Search for: Tourigny, Martine; Search for: Lyon, Robbe C.; Search for: Sabsabi, Mohamad1 |
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| Affiliation | - National Research Council of Canada. NRC Industrial Materials Institute
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| Format | Text, Article |
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| Conference | IFPAC 2008, January 27-30, 2008, Baltimore, Maryland, USA |
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| Abstract | In many pharmaceutical manufacturing applications, Laser Induced Breakdown Spectroscopy (LIBS) makes possible at-line rapid measurements of many formulation ingredients as well as the possibility of stand-off analysis, in-situ, in-line and on line process monitoring. These capabilities make LIBS an attractive PAT sensor technology that can be introduced virtually everywhere in the pharmaceutical manufacturing process. Molecular Laser-Induced Breakdown Spectroscopy (MO-LIBS) uses the molecular band emission of small diatomic fragments and chemometrics to establish predictive model that allow quantitative measurements. This innovative approach allows a complete simultaneous formulation ingredients analysis as well as the prediction of pharmaceutical manufacturing changes. The results obtained in this work highlight the potential for MO-LIBS to be more widely applied to process monitoring and quality control of pharmaceutical products. |
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| Publication date | 2008-01-27 |
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| In | |
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| Language | English |
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| Peer reviewed | No |
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| NRC number | NRCC 54242 |
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| NPARC number | 18335899 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | f360f69a-e20a-451d-b679-4980084943a0 |
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| Record created | 2011-07-29 |
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| Record modified | 2020-08-12 |
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