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Eukaryotic initiation factor 6 selectively regulates Wnt signaling and beta-catenin protein synthesis

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1038/sj.onc.1210667
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Affiliation
  1. National Research Council of Canada. Aquatic and Crop Resource Development
FormatText, Article
Abstract
Eukaryotic initiation factor 6 (eIF6), an essential protein important in ribosome biosynthesis and assembly, was identified as an interacting partner of the β-catenin C terminus in the yeast two-hybrid assay. Independent studies identified Drosophila eIF6 (DeIF6) in a genetic screen designed to detect new genes involved in the regulation of the Wnt/Wg (wingless) pathway. Ectopic expression of DeIF6 in wing discs results in a Wg phenotype. Expression of eIF6 in adenomatous polyposis coli (APC)-mutant colon cancer cells, which express high levels of active β-catenin, showed that eIF6 selectively inhibits the Wnt pathway at the level of β-catenin protein independently of proteasomal degradation. Incorporation of radiolabeled amino acids into β-catenin was selectively decreased in cells that overexpressed eIF6. A similar inverse relationship of the two proteins was observed in the APCmin/+ mouse intestine, in which β-catenin levels are very high. Taken together these data reveal a link between eIF6 and Wnt signaling, perhaps at the level of ribosome recycling on β-catenin mRNA
Publication date
In
  • Oncogene 27 (30 July 2007): 755–762.
LanguageEnglish
Peer reviewedYes
NRC publication
This is a non-NRC publication

"Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.

NRC number1775
NPARC number3538441
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Record identifierf932caea-975c-46d6-88bc-6fd222fefe04
Record created2009-03-01
Record modified2020-05-10
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