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Blepharocalyxins C−E, three new dimeric diarylheptanoids, and related compounds from the seeds of Alpinia blepharocalyx

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1021/np000493l
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Affiliation
  1. National Research Council of Canada. Aquatic and Crop Resource Development
FormatText, Article
Abstract
Three novel diarylheptanoids, blepharocalyxins C−E (5−7), together with four new (1−4) and one known (8) diarylheptanoids bearing a tetrahydropyran ring were isolated from the residual fraction of an EtOH extract of the seeds of Alpinia blepharocalyx. The structures and the stereochemistry at the chiral centers of the new diarylheptanoids were elucidated by spectroscopic techniques including 2D NMR spectroscopy. Blepharocalyxins C−E (5−7) have a novel carbon framework and are dimeric diarylheptanoids consisting of two diarylheptanoid units. Blepharocalyxin D (6) showed potent antiproliferative activity against murine colon 26-L5 carcinoma cells (ED50, 3.61 μM), while against human HT-1080 fibrosarcoma cells, blepharocalyxin E (7) showed potent activity (ED50, 9.02 μM).
Publication date
In
  • Journal of Natural Products 64, no. 4 (11 April 2001): 491–496.
LanguageEnglish
Peer reviewedYes
NRC publication
This is a non-NRC publication

"Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.

NPARC number21274809
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Record identifierfea70d1e-a65c-4c58-8043-2655553617b8
Record created2015-04-13
Record modified2020-03-27
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