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DNA methylation of birthweight–blood pressure genes and changes of blood pressure in response to weight-loss diets in the POUNDS lost trial

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1161/HYPERTENSIONAHA.123.20864
AuthorSearch for: ORCID identifier: https://orcid.org/0000-0002-3885-4103; Search for: ORCID identifier: https://orcid.org/0000-0002-6637-6428; Search for: 1; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ORCID identifier: https://orcid.org/0000-0001-5218-6941; Search for: ; Search for: ORCID identifier: https://orcid.org/0000-0003-1341-1995; Search for: ORCID identifier: https://orcid.org/0000-0002-8041-7791
Affiliation
  1. National Research Council of Canada. Digital Technologies
FormatText, Article
Subjectblood pressure; weight-loss; diets; DNA methylation; obesity
Abstract
Background: DNA methylation (DNAm) may play a critical role in bridging prenatal adverse events and cardiometabolic disorders including hypertension in later life. Methods: We included 672 adult participants with overweight or obesity, who participated in a 2-year randomized weight-loss dietary intervention study. We defined the regional DNAm levels as the average methylation level of 5’-cytosine-phosphate-guanine-3’ within 500 bp of LINC00319 (cg01820192), ATP2B1 (cg00508575), and LMNA (cg12593793), respectively. Generalized linear regression models were used to assess the association between the regional DNAm and 2-year blood pressure changes. Trajectory analysis was used to identify subgroups that shared a similar underlying trajectory of 2-year blood pressure changes. Results: The regional DNAm at LINC00319 , showed significantly different associations with 2-year changes in systolic blood pressure and diastolic blood pressure among participants assigned to low- or high-fat diets ( P for interaction < 0.05 for all). In response to the low-fat diet, per SD higher regional DNAm at LINC00319 was associated with greater reductions in both 2-year changes in systolic blood pressure (β, −1.481; P =0.020) and diastolic blood pressure (β, −1.096; P =0.009). Three trajectories of changes in systolic blood pressure or diastolic blood pressure were identified, and participants with higher regional DNAm at LINC00319 were more likely to experience and maintain decreased systolic blood pressure and diastolic blood pressure (odds ratio of being in decrease-stable versus stable [95% CI], 1.542 [1.146–2.076] and 1.463 [1.125–1.902]). Conclusions: Our findings suggest that DNAm could be a metabolic memory bridging early and later life, and an indicator of more benefits from eating a low-fat weight-loss diet.
Publication date
PublisherAmerican Heart Association
Ovid Technologies (Wolters Kluwer Health)
In
  • Hypertension 80, no. 6 (June 2023): 1223–1230.
LanguageEnglish
Peer reviewedYes
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Record identifierff9609b4-61f0-4d36-a0dd-77fc266ff5a0
Record created2023-04-14
Record modified2024-05-01
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