DOI | Trouver le DOI : https://doi.org/10.1016/0006-291X(87)90972-7 |
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Auteur | Rechercher : Franks, D.; Rechercher : Whitfield, James; Rechercher : Durkin, J. |
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Format | Texte, Article |
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Résumé | Incubation at 41°C stops the proliferation of tsK-NRK rat kidney cells in serum-deficient medium by inactivating the mitogenic/oncogenic thermolabile viral K-RAS protein that is produced in these cells. Dropping the temperature to 36°C reactivates the viral K-RAS protein which stimulates the serum-starved quiescent cells to resume proliferating without added serum factors. Here it is shown that while the reactivated viral protein does not by itself significantly stimulate adenylate cyclase, it greatly increases the stimulability of adenylate cyclase by cholera toxin. The data suggest that the viral K-RAS protein directly or indirectly affects adenylate cyclase by inactivating the Gi inhibitory component of the membrane associated enzyme. |
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Date de publication | 1987-09-15 |
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Maison d’édition | Elsevier |
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Dans | |
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Langue | anglais |
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Publications évaluées par des pairs | Oui |
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Numéro du CNRC | FRANKS1987A |
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Numéro NPARC | 9360723 |
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Exporter la notice | Exporter en format RIS |
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Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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Identificateur de l’enregistrement | 046130ee-860f-4ce3-bf83-d94788c40add |
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Enregistrement créé | 2009-07-10 |
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Enregistrement modifié | 2020-03-17 |
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