| Téléchargement | - Voir la version finale : Characterization of extremely drug-resistant and hypervirulent Acinetobacter baumannii AB030 (PDF, 2.3 Mio)
- Voir les données supplémentaires : Characterization of extremely drug-resistant and hypervirulent Acinetobacter baumannii AB030 (PDF, 4.4 Mio)
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| DOI | Trouver le DOI : https://doi.org/10.3390/antibiotics9060328 |
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| Auteur | Rechercher : Singh, ManuIdentifiant ORCID : https://orcid.org/0000-0001-9396-1502; Rechercher : De Silva, P. Malaka; Rechercher : Al-Saadi, Yasser; Rechercher : Switala, Jacek; Rechercher : Loewen, Peter C.Identifiant ORCID : https://orcid.org/0000-0003-4507-4356; Rechercher : Hausner, GeorgIdentifiant ORCID : https://orcid.org/0000-0002-6541-1148; Rechercher : Chen, Wangxue1Identifiant ORCID : https://orcid.org/0000-0003-0958-7728; Rechercher : Hernandez, Ismael; Rechercher : Castillo-Ramirez, Santiago; Rechercher : Kumar, AyushIdentifiant ORCID : https://orcid.org/0000-0001-6395-7932 |
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| Affiliation | - Conseil national de recherches du Canada. Thérapeutique en santé humaine
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| Format | Texte, Article |
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| Sujet | multidrug resistance; virulence; gram-negative; comparative genomics; insertion elements |
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| Résumé | Acinetobacter baumannii is an important nosocomial bacterial pathogen. Multidrug-resistant isolates of A. baumannii are reported worldwide. Some A. baumannii isolates display resistance to nearly all antibiotics, making treatment of infections very challenging. As the need for new and effective antibiotics against A. baumannii becomes increasingly urgent, there is a need to understand the mechanisms of antibiotic resistance and virulence in this organism. In this work, comparative genomics was used to understand the mechanisms of antibiotic resistance and virulence in AB030, an extremely drug-resistant and hypervirulent strain of A. baumannii that is a representative of a recently emerged lineage of A. baumannii International Clone V. In order to characterize AB030, we carried out a genomic and phenotypic comparison with LAC-4, a previously described hyper-resistant and hypervirulent isolate. AB030 contains a number of antibiotic resistance- and virulence-associated genes that are not present in LAC-4. A number of these genes are present on mobile elements. This work shows the importance of characterizing the members of new lineages of A. baumannii in order to determine the development of antibiotic resistance and virulence in this organism. |
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| Date de publication | 2020-06-17 |
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| Maison d’édition | MDPI |
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| Licence | |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Identificateur | antibiotics9060328 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 05d6a9da-503e-4c2d-be75-cd201feba26e |
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| Enregistrement créé | 2021-04-14 |
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| Enregistrement modifié | 2021-04-19 |
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