| DOI | Trouver le DOI : https://doi.org/10.1515/BC.2003.094 |
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| Auteur | Rechercher : Nägler, Dorit K.; Rechercher : Ménard, Robert1 |
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| Affiliation | - Conseil national de recherches du Canada. Institut de recherche en biotechnologie du CNRC
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| Format | Texte, Article |
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| Sujet | Cysteine; genome; pharmaceutical; Cathepsin; Papain-like; Peptidase; Specificity |
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| Résumé | Recent progress in the identification and partial characterization of novel genes encoding cysteine proteases of the papain family has considerably increased our knowledge of this family of enzymes. Kinetic data available to date for this large family indicate relatively broad, overlapping specificities for most enzymes, thus inspiring a growing conviction that they may exhibit functional redundancy. This is also supported in part by phenotypes of cathepsin knockout mice and suggests that several proteases can substitute for each other to degrade or process a given substrate. On the other hand, specific functions of one particular protease have also been documented. In addition, differences in cellular distribution and intracellular localization may contribute to defining specific functional roles for some of these proteases. |
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| Date de publication | 2003-06 |
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| Dans | |
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| Note | 2003300001860423-0014See Contents-PageJournal |
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| Langue | anglais |
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| Numéro du CNRC | 46190 |
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| Numéro NPARC | 3539452 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 0ede53f3-e20d-4dae-a6f0-ec0c137a5136 |
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| Enregistrement créé | 2009-03-01 |
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| Enregistrement modifié | 2020-04-02 |
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