| Téléchargement | - Voir le manuscrit accepté : Characterization of cryoinjury-induced infarction with manganese-and-gadolinium-enhanced MRI and optical spectroscopy in pig hearts (PDF, 847 Kio)
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| DOI | Trouver le DOI : https://doi.org/10.1016/j.mri.2010.02.001 |
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| Auteur | Rechercher : Yang, Yanmin1; Rechercher : Sun, Jiankang1; Rechercher : Gervai, Patricia1; Rechercher : Gruwel, Marco L.1; Rechercher : Jilkina, Olga1; Rechercher : Gussakovsky, Eugene1; Rechercher : Yang, Xi; Rechercher : Kupriyanov, Valery1 |
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| Affiliation | - Conseil national de recherches du Canada. Institut du biodiagnostic du CNRC
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| Format | Texte, Article |
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| Sujet | Acute and chronic cryoinjury; No-reflow embolization; Gd-enhanced MRI; Mn-enhanced MRI; Optical imaging and spectroscopy |
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| Résumé | Purpose: To investigate progression of cryoinjury in pigs using contrast-enhanced magnetic resonance imaging (MRI) as well as optical spectroscopy and imaging. Methods: Cryoinjury was produced in 16 pigs in vivo and investigated using Gd-and Mn-enhanced MRI, optical imaging /spectroscopy and histology in acute and chronic setting up to 4 weeks after the injury. Results: (1) Acute cryoinjury resulted in formation of a lesion with a severely reduced rate of sub-epicardial indocyanine green (intravascular optical flow tracer) passage. In vivo late Gd-enhanced MRI showed a ?10 mm deep hypointense area that was surrounded by a hyperintense rim while ex vivo Mn-enhanced MRI (MEMRI) detected a homogenous hypointense zone. Histological and spectroscopic examination revealed embolic erythrocytes blockages within the cryolesion with a thin necrotic rim neighboring the normal myocardium. (2) Chronic 4-week cryoinjury was characterized by uniform Gd-enhancement, whereas MEMRI revealed reduced Mn2+enhancement. Histological examination showed replacement of the cryoinjured myocardium by scar tissue. Conclusions: Acute cryoinjury resulted in formation of a no-reflow core embolized by erythrocytes and surrounded by a rim of necrotic tissue. Upon injury progression, the no-reflow zone shrunk and was completely replaced with scar tissue by 4 weeks after injury. |
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| Date de publication | 2010-04-15 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 17653076 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 0f9a8683-e9e3-445b-a66d-c6172979949d |
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| Enregistrement créé | 2011-04-03 |
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| Enregistrement modifié | 2020-04-17 |
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