| DOI | Trouver le DOI : https://doi.org/10.1021/ac5005635 |
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| Auteur | Rechercher : Mostaço-Guidolin, L.B.1; Rechercher : Kohlenberg, E.K.1; Rechercher : Smith, M.1; Rechercher : Hewko, M.1; Rechercher : Major, A.; Rechercher : Sowa, M.G.1; Rechercher : Ko, A.C.-T.1 |
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| Affiliation | - Conseil national de recherches du Canada. Dispositifs médicaux
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| Format | Texte, Article |
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| Sujet | Blood vessels; Optical correlation; Atherosclerotic lesions; Atherosclerotic plaque; Fluorescence imaging; Microscopic image; Non-linear optical; Numerical matrices; Positive correlations; Quantitative approach; Diseases |
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| Résumé | Quantification of atherosclerosis has been a challenging task owing to its complex pathology. In this study, we validated a quantitative approach for assessing atherosclerosis progression in a rabbit model using a numerical matrix, optical index for plaque burden, derived directly from the nonlinear optical microscopic images captured on the atherosclerosis-affected blood vessel. A positive correlation between this optical index and the severity of atherosclerotic lesions, represented by the age of the rabbits, was established based on data collected from 21 myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits with age ranging between new-born and 27 months old. The same optical index also accurately identified high-risk locations for atherosclerotic plaque formation along the entire aorta, which was validated by immunohistochemical fluorescence imaging. © 2014 American Chemical Society. |
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| Date de publication | 2014 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 21272255 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 1439c653-f05f-41c4-aa7a-83b776fb6e16 |
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| Enregistrement créé | 2014-07-23 |
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| Enregistrement modifié | 2020-04-22 |
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