A new member of the troponin C superfamily: comparison of the primary structures of rat oncomodulin and rat parvalbumin

Autre titre	A new member of the troponin C superfamily - comparison of the primary structures of rat oncomodulin and rat parvalbumin
DOI	Trouver le DOI : https://doi.org/10.1007/BF01121034
Auteur	Rechercher : Macmanus, J.¹; Rechercher : Watson, David¹; Rechercher : Yaguchi, M.¹
Affiliation	Conseil national de recherches du Canada
Format	Texte, Article
Sujet	isoelectric point; primary structure; tumour protein; extensive homology; homologous position
Résumé	When the amino-acid sequence of the 108-residue, rat tumour calcium-binding protein, oncomodulin, was aligned with that of rat muscle parvalbumin, 55 homologous positions were found, with an additional 33 single base-pair substitutions. This extensive homology, with virtual identity of the calcium-binding domains, signalled oncomodulin to be a member of the troponin C superfamily. The presence of Cys-18 and Phe-66 in oncomodulin, plus its isoelectric point of 3.9) suggest that this tumour protein is a 8-parvaJbumin, rather than a muscle α-parvalbumin.
Date de publication	1983-11-01
Maison d’édition	Springer
Dans	Bioscience Reports 3 : 1071–1075.
Langue	anglais
Publications évaluées par des pairs	Oui
Identificateur	NRC-IBS-MACMANUS1983C
Numéro NPARC	9372159
Exporter la notice	Exporter en format RIS
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Identificateur de l’enregistrement	14fad3c8-19ee-48cd-ba9b-d1036a935e0b
Enregistrement créé	2009-07-10
Enregistrement modifié	2020-05-19