| DOI | Trouver le DOI : https://doi.org/10.1016/j.bmc.2008.09.025 |
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| Auteur | Rechercher : Prakesch, Michael1; Rechercher : Bijian, Krikor; Rechercher : Campagna-Slater, Valérie; Rechercher : Quevillon, Sophie1; Rechercher : Joseph, Reni1; Rechercher : Wei, Chang-Qing1; Rechercher : Sesmilo, Esther1; Rechercher : Reayi, Ayub1; Rechercher : Poondra, Rajamohan R.1; Rechercher : Barnes, Michael L.; Rechercher : Leek, Donald M.; Rechercher : Xu, Bin; Rechercher : Lougheed, Caroline; Rechercher : Schapira, Matthieu; Rechercher : Alaoui-Jamali, Moulay; Rechercher : Arya, Prabhat1 |
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| Affiliation | - Conseil national de recherches du Canada. Institut Steacie des sciences moléculaires du CNRC
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| Format | Texte, Article |
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| Sujet | natural products; natural product-like compounds; small-molecule chemical probes; diversity-oriented synthesis; focal adhesion kinase; signaling networks; cell migration; anti-cancer agents; docking |
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| Résumé | Inspired by bioactive indoline alkaloid natural products, here, we report a divergent synthesis approach that led to skeletally diverse indoline alkaloid-inspired compounds. The natural product-inspired compounds obtained were then subjected to a series of in vitro and cellular assays to examine their properties as modulators of focal adhesion kinase (FAK) activity. This study resulted in the identification of a promising lead inhibitor of FAK (42), which also showed activity in a wound healing and cell invasion assay. The in silico study of the lead compound (42) was also undertaken. |
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| Date de publication | 2008-11 |
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| Maison d’édition | Elsevier |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 12328434 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 173e4574-524b-44f2-af7c-ab82af098ea8 |
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| Enregistrement créé | 2009-09-10 |
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| Enregistrement modifié | 2020-04-15 |
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