Synthesis of a Novel Radical Trapping and Carbonyl Group Trapping Anti-AGE Agent: A Pyridoxamine Analogue for Inhibiting Advanced Glycation (AGE) and Lipoxidation (ALE) End Products

DOI	Trouver le DOI : https://doi.org/10.1021/ol0348147S1523-7060(03)04814-4
Auteur	Rechercher : Culbertson, S.; Rechercher : Enright, Gary¹; Rechercher : Ingold, Keith¹
Affiliation	Conseil national de recherches du Canada. Institut Steacie des sciences moléculaires du CNRC
Format	Texte, Article
Résumé	Pyridoxamine is known to be an effective inhibitor of both advanced glycation (AGE) and advanced lipoxidation (ALE) end products. The synthesis of a novel multifunctional AGE and ALE inhibitor, 6-dimethylaminopyridoxamine (dmaPM, 11) is described. The 6-dimethylamino substituent increases the radical trapping ability of pyridoxamine's phenolic group. Results obtained during ribose glycations show that both the new dmaPM and a known strong radical trapping agent, 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox), prevent intermolecular protein cross-linking more effectively than pyridoxamine (PM).
Date de publication	2003-07-24
Dans	Organic Letters 5, nº 15 (24 juillet 2003) : 2659–2662.
Numéro NPARC	12327504
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Identificateur de l’enregistrement	233a2001-448c-4fe9-b35d-8d562e44dce9
Enregistrement créé	2009-09-10
Enregistrement modifié	2020-04-02