| Téléchargement | - Voir le manuscrit accepté : Using multimodal femtosecond CARS imaging to determine plaque burden in luminal atherosclerosis (PDF, 813 Kio)
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| DOI | Trouver le DOI : https://doi.org/10.1117/12.873867 |
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| Auteur | Rechercher : Ko, Alex C.-T.1; Rechercher : Mostaço-Guidolin, Leila B.; Rechercher : Ridsdale, Andrew2; Rechercher : Pegoraro, Adrian F.2; Rechercher : Smith, Michael S. D.1; Rechercher : Slepkov, Aaron2; Rechercher : Hewko, Mark D.1; Rechercher : Kohlenberg, Elicia K.1; Rechercher : Schattka, Bernie1; Rechercher : Stolow, Albert2; Rechercher : Sowa, Michael G.1 |
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| Affiliation | - Conseil national de recherches du Canada. Institut du biodiagnostic du CNRC
- Conseil national de recherches du Canada. Institut Steacie des sciences moléculaires du CNRC
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| Format | Texte, Article |
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| Conférence | Multiphoton Microscopy in the Biomedical Sciences XI, 23 January 2011, San Francisco, California, USA |
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| Sujet | multimodal; femtosecond CARS; atherosclerosis; luminal imaging; plaque burden; texture analysis; first-order statistics; myocardial infarction-prone rabbit |
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| Résumé | Luminal atherosclerosis imaging was demonstrated by multimodal femtosecond CARS microscopy (MM-CARS). Using a myocardial infarction-prone rabbit model of atherosclerosis, this study demonstrated the utility of multimodal CARS imaging in determining atherosclerotic plaque burden through two types of image analysis procedures. Firstly, multimodal CARS images were evaluated using a signal-intensity parameter based on intensity changes derived from the multi-channel data (e.g. TPEF, SHG and CARS) to classify plaque burden within the vessel. Secondly, the SHG images that mainly correspond to collagen fibrils were evaluated using a texture analysis model based on the first-order statistical (FOS) parameters of the image histogram. Correlation between FOS parameters of collagen images with atherosclerosis plaque burden was established. A preliminary study of using spectroscopic CARS in identifying the different lipid components within the plaque was also discussed. |
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| Date de publication | 2011-02-22 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 19697994 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 294513cf-75a8-4b28-81a3-2ef35e7e2539 |
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| Enregistrement créé | 2012-03-22 |
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| Enregistrement modifié | 2020-04-21 |
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