| DOI | Trouver le DOI : https://doi.org/10.1109/TMI.2002.806275 |
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| Auteur | Rechercher : Ramjiawan, Bram1; Rechercher : Ariano, Robert E.; Rechercher : Mantsch, Henry H.1; Rechercher : Maiti, Pradip; Rechercher : Jackson, Michael1 |
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| Affiliation | - Conseil national de recherches Canada. Institut du biodiagnostic du CNRC
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| Format | Texte, Article |
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| Résumé | We have used immunofluorescence imaging to study binding of a monoclonal antibody fragment to subcutaneously implanted human melanoma cells in nude mice. The data acquired using this nontraditional approach was then analyzed using standard pharmacokinetic methods to produce estimates of k/sub e/ (0.06 h/sup -1/), t/sub 1/2/ (16 h), mean residency time (23.4 h) and percent exposure of the antibody to the tumor (40%). To our knowledge this is the first time standard pharmacokinetic analyzes have been conducted on immunofluorescence imaging data. The combination of this novel imaging technique and standard pharmacokinetic analytical methods should prove to be a useful tool for comparing the properties of antibody fragments in animal models. |
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| Date de publication | 2002-10 |
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| Dans | |
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| Numéro du CNRC | 1969 |
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| Numéro NPARC | 9147671 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 2c2dbcc6-10f0-4197-b081-afbcb91370ee |
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| Enregistrement créé | 2009-06-25 |
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| Enregistrement modifié | 2020-03-30 |
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