| DOI | Trouver le DOI : https://doi.org/10.1016/j.tetlet.2012.08.038 |
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| Auteur | Rechercher : Legault, Marc C.B.1; Rechercher : Mckay, Craig S.1; Rechercher : Moran, Joseph1; Rechercher : Lafreniere, Matthew A.1; Rechercher : Pezacki, John paul1 |
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| Affiliation | - Conseil national de recherches du Canada. Dispositifs médicaux
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| Format | Texte, Article |
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| Sujet | N-heterocyclic carbenes; Intramolecular cyclization; Diels–Alder cycloaddition |
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| Résumé | Alkyne-tethered imidazole and 1,2,4-triazole-based N-heterocyclic carbene precursors have been prepared and studies of the intramolecular reactions of carbenes are performed. Products consistent with intramolecular cyclizations and subsequent rearrangements were observed. Mechanistic studies using crossover experiments showed that the products did arise from intramolecular carbene additions. The reactions are proposed to go through vinylogous diaminocarbene intermediates similar to vinylogous dialkoxycarbenes formed during Boger cycloaddition reactions. Imidazole substituted dienes were observed to be the major products of tandem cyclization and elimination reactions that were observed for imidazole-based N-heterocyclic carbenes. |
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| Date de publication | 2012-10 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Identificateur | S0040403912013974 |
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| Numéro NPARC | 21268743 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 332a1863-5527-4e37-ad03-6e454a58fc74 |
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| Enregistrement créé | 2013-11-12 |
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| Enregistrement modifié | 2020-04-21 |
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