| DOI | Trouver le DOI : https://doi.org/10.1088/0957-4484/23/4/045103 |
|---|
| Auteur | Rechercher : Hao, Yuzhi1; Rechercher : Yang, Xiaoyang; Rechercher : Song, Steven; Rechercher : Huang, Min; Rechercher : He, Chuan; Rechercher : Cui, Mingyang; Rechercher : Chen, Jie |
|---|
| Affiliation | - Conseil national de recherches du Canada. Institut national de nanotechnologie
|
|---|
| Format | Texte, Article |
|---|
| Sujet | Biodistributions; Biomedical applications; Cell uptake; In-vivo; Nanoparticle sizes; SEM and TEM; Sodium salt; Structural similarity; Biocompatibility; Cell membranes; Thermoplastics; Polyethylene glycols; 1 palmitoyl 2 oleoylglycero 3 phosphoglycerol; 1-palmitoyl-2-oleoylglycero-3-phosphoglycerol; macrogol derivative; metal nanoparticles; phosphatidylglycerol; cell death; drug effect; endocytosis; tumor cell line; ultrastructure; Phosphatidylglycerols; Polyethylene Glycols |
|---|
| Résumé | Recently, there has been a lot of interest in using gold nanoparticles (GNPs) for biomedical applications due to their biocompatibility. To increase GNP cell uptake and circulation half-life, and to improve its bio-distribution invivo, we chose to coat GNPs with 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1- rac-glycerol) (sodium salt) (POPG) and polyethylene glycol (PEG). Two different methods were used to synthesize POPG-GNPs or PEG-GNPs, but the resulting nanoparticle sizes and morphologies were similar. Under the same incubation conditions, POPG-GNPs can be uptaken quicker than PEG-GNPs by cellsspecifically, the maximum uptake was 8h versus 16h after incubation. In addition, the uptake amount of POPG-GNPs was more than that of PEG-GNPs. The uptake processes were confirmed by SEM and TEM images. The main reason for the greater uptake of POPG-GNPs can be attributed to the structural similarities between the POPG coating and the cell membrane as well as GNP aggregation. |
|---|
| Date de publication | 2012-01-06 |
|---|
| Dans | |
|---|
| Langue | anglais |
|---|
| Publications évaluées par des pairs | Oui |
|---|
| Numéro NPARC | 21270274 |
|---|
| Exporter la notice | Exporter en format RIS |
|---|
| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
|---|
| Identificateur de l’enregistrement | 338e9260-03b5-4873-8840-694312fb157e |
|---|
| Enregistrement créé | 2014-01-20 |
|---|
| Enregistrement modifié | 2020-04-21 |
|---|
