| Téléchargement | - Voir la version finale : Bovine dendritic cell activation, T cell proliferation and antibody responses to foot-and-mouth disease, is similar with inactivated virus and virus like particles (PDF, 1.0 Mio)
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| DOI | Trouver le DOI : https://doi.org/10.3389/fvets.2020.00594 |
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| Auteur | Rechercher : Quattrocchi, Valeria; Rechercher : Bidart, Juan; Rechercher : Mignaqui, Ana Clara; Rechercher : Ruiz, Vanesa; Rechercher : Ferella, Alejandra; Rechercher : Langellotti, Cecilia; Rechercher : Gammella, Mariela; Rechercher : Ferraris, Sergio; Rechercher : Carrillo, Jorge; Rechercher : Wigdorovitz, Andres; Rechercher : Durocher, Yves1; Rechercher : Cardillo, Sabrina Beatriz; Rechercher : Charleston, Bryan; Rechercher : Zamorano, Patricia Inés |
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| Affiliation | - Conseil national de recherches du Canada. Thérapeutique en santé humaine
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| Format | Texte, Article |
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| Sujet | FMDV; empty capsids; dendritic cells; bovine; A/ARG/2001 |
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| Résumé | Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals that causes severe economic losses in the livestock industry. Currently available vaccines are based on the inactivated FMD virus (FMDV). Although inactivated vaccines have been effective in controlling the disease, they have some disadvantages. Because of these disadvantages, investigations are being made to produce vaccines in low containment facilities. The use of recombinant empty capsids (also referred as Virus Like Particles, VLPs) has been reported to be a promising candidate as a subunit vaccine because it avoids the use of virus in the vaccine production and conserves the conformational epitopes of the virus. Mignaqui and collaborators have produced recombinant FMDV empty capsids from serotype A/ARG/2001 using a scalable technology in mammalian cells that elicited a protective immunity against viral challenge in a mouse model. However, further evaluation of the immune response elicited by these VLPs in cattle is required. In the present work we compare the effect that VLPs or inactivated FMDV has on bovine dendritic cells and the humoral response elicited in cattle after a single vaccination. |
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| Date de publication | 2020-09-30 |
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| Maison d’édition | Frontiers Media SA |
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| Licence | |
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| Dans | |
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| Note | yes |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Publication du CNRC | Cette publication n’est pas du CNRCCe sont des publications qui ont été rédigées par un auteur du CNRC, mais avant que celui-ci soit employé du CNRC. |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 3911c0e4-23de-4ae9-90ad-97fae2c90778 |
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| Enregistrement créé | 2021-04-14 |
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| Enregistrement modifié | 2021-09-21 |
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